Recent Highlights

1. Firestone, K, Gopalakrishna, KP, Rogers, LM, Peters, A, Gaddy, JA, Nichols, CM, Hall, MH, Varela HN, Carlin, SM, Hillebrand, GH, Giacobe, EJ, Aronoff, DM, Hooven, TA. A CRISPRi library screen in group B Streptococcus identifies surface immunogenic protein (Sip) as a mediator of multiple host interactions. Infection and Immunity 93, e0057324. 2025.

2. Megli, CJ, Carlin, SM, Giacobe, EJ, Hillebrand, GH & Hooven, TA. Virulence and pathogenicity of group B Streptococcus: Virulence factors and their roles in perinatal infection. Virulence 16, 2451173. 2025.

3. Megli, CJ, DePuyt, AE, Goff, JP, Munyoki, SK, Hooven, TA, Jašarević, E, “Diet influences community dynamics following vaginal group B streptococcus colonization.” Microbiology Spectrum 12, e0362323. 2024.

4. Bhavana, VH, Hillebrand, GH, Gopalakrishna, KP, Rapp, RA, Ratner, AJ, Tettelin, H, Hooven, TA. “A group B Streptococcus indexed transposon mutant library to accelerate genetic research on an important perinatal pathogen.” Microbiology Spectrum 11, e02046-23. 2023.

5. Gopalakrishna, KP, Hillebrand, GH, Bhavana, VH, Elder, JL, D’mello, A, Tettelin, H, Hooven, TA. “Group B Streptococcus Cas9 variants provide insight into programmable gene repression and CRISPR-Cas transcriptional effects.” Communications Biology. 2023, 6(620) [* equal contribution to authorship].

6. Keith, MF, Gopalakrishna, KP, Bhavana, VH, Hillebrand, GH, Elder, JL, Megli, CJ, Sadovsky, Y, Hooven, TA. “Nitric oxide production and effects in group B Streptococcus chorioamnionitis.” Pathogens. 2022, 11(1115).

7. Lin, YC, Salleb-Aouissi, A, Hooven, TA. “Interpretable prediction of necrotizing enterocolitis from machine learning analysis of premature infant stool microbiota.” BMC Bioinformatics. 2022, 23(104).

8. Dammann, AN, Chamby, AB, Gonzalez, FJ, Sharp, ME, Flores, K, Shahi, I, Dongas, S, Hooven, TA, Ratner, AJ. “Group B Streptococcus capsular serotype alters vaginal colonization fitness.” Journal of Infectious Diseases. 2021, doi:10.1093/infdis/jiab559.

9. Kim G-L, Hooven TA, Norambuena J, Li B, Boyd JM, Yang JH, Parker D. “Growth and stress tolerance comprise independent metabolic strategies critical for Staphylococcus aureus Infection.” mBio. 2021, 12: e00814-21.

10. Dammann AN, Chamby AB, Catomeris AJ, Davidson KM, Tettelin H, van Pijkeren J-P, Gopalakrishna KP, Keith MF, Elder JL, Ratner AJ, Hooven TA. “Genome-wide fitness analysis of group B Streptococcus in human amniotic fluid reveals a transcription factor that controls multiple virulence traits.” PLOS Pathogens. 2021, 17(3): e1009116.

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